Neighborhoods: SOMA, Mission, North Beach
Dinner: Thai Osha, Dosa, Yoshi's, farmerbrown, ThirstyBear (for the love of all that is good, don't go to Cheesecake Factory!)
Clubs: ehh... I'm a little rusty on this, but the stand-bys when I was going out all the time were Suite 181, Club NV, and Glas Kat. I also hear Ruby Skye is fun. All of the best club experiences I've ever had were at special events;
the crowd is way more chill and mature (read: no drunken fights/little fake-ID girls who can't handle their booze.) Try to do some research with companies that put on themed events on Facebook.
Late night snack (i.e. drunk eats): Hapa SF, El Farolito, Mel's Drive In, Asian crepes, anything on a cart (seriously)
Hotels: Intercontinental (on Howard, not the Mark Hopkins), W, Parc 55, Westin St. Francis, Hotel Nikko
Brunch (i.e. hangover food): Foreign Cinema, Lime, Brenda's French Soul Food, Top of the Mark
I must say, AsiaSF is an only-in-SF experience. The food is just OK, but it's a ton of fun. My friend had her whole bachelorette party there and it was a blast!
